REGISTRATION
ISN-KDIGO Webinar Series on Complement in GN – Dissecting the Role of Complement in Glomerulonephritis with a Focus on C3G
C3 glomerulopathy (C3G), is a prototypical disorder of complement over activation with prominent C3 deposition on the renal biopsy. Complement dysregulation occurs predominantly in the fluid phase but also in the glomerular microenvironment. The alternative pathway is the key driver of pathology in C3G with terminal pathway recruitment also seen. The disease is largely acquired with activating autoantibodies (e.g. nephritic factor) and only rarely genetic. This detailed understanding of the underlying pathophysiology of disease has led to ongoing clinical trials of the next generation of alternative pathway complement inhibitors.This webinar will cover the role of complement in various forms of glomerulonephritis, emphasizing C3G, and review the pathophysiology of the complement system (classical, lectin, and alternate pathways). Challenges around diagnosis, current recommendations for evaluating the complement system, and recent and evolving guidelines for management of C3 glomerulopathy will be presented for discussion. The role of novel therapeutics in this setting will also be touched upon.
This webinar is developed with support from Novartis.
Learning Objectives:
- To understand the pathophysiology of the complement system in glomerulonephritis
- To understand the approach to the diagnosis of complement mediated glomerulonephritis
- To appreciate the evolving aspects of management of complement mediated glomerulonephritis