Pathophysiology: current hypothesized causes
The causes of CKDu are not yet established, and current hypotheses are evaluating various possible etiologies, including:
Click on the infographic for latest relevant articles.
An integrative study of the genetic, social, and environmental determinants of chronic kidney disease characterized by tubulointerstitial damages in the North Central Region of Sri Lanka. Nanayakkara S, Senevirathna ST, Abeysekera T, Chandrajith R, Ratnatunga N, Gunarathne ED, Yan J, Hitomi T, Muso E, Komiya T, Harada KH, Liu W, Kobayashi H, Okuda H, Sawatari H, Matsuda F, Yamada R, Watanabe T, Miyataka H, Himeno S, Koizumi A. J Occup Health. 2014;56(1):28-38.
Risk factors for reduced glomerular filtration rate in a Nicaraguan community affected by Mesoamerican nephropathy. Raines N, González M, Wyatt C, Kurzrok M, Pool C, Lemma T, et al. MEDICC Rev. 2014;16:16–22