Tag - atypical hemolytic uremic syndrome (aHUS)

aHUS (atypical hemolytic uremic syndrome) is a very rare genetic disease that causes tiny blood clots to form in blood vessels, blocking blood flow to important organs. aHUS can cause kidney failure, heart disease and other serious health problems. There is no known cure for aHUS, but it can be treated.

ISN Journal Editorial Selections on aHUS Management, Rituximab Therapy, Methylmalonic Acidemia, and Rare Kidney Diseases

Kidney International® Outcomes From the International Society of Nephrology Hemolytic Uraemic Syndromes International Forum  The 2023 ISN aHUS Forum brought together global experts to discuss key challenges in managing complement-mediated hemolytic uraemic syndromes (HUS), including nomenclature, biomarkers, and treatment protocols. Key areas for future research were identified, such as genetic predisposition, optimal complement inhibitor use, and improving...

New! Narrated Animation on Complement System Dysregulation and Its Impact on the Kidney–Watch it Now!

The kidney is particularly susceptible to damage by complement. Activation of the complement system is tightly regulated by a series of soluble and membrane-bound proteins. Failure of these checking mechanisms is one of the major causes of complement-mediated kidney diseases. Evidence of specific complement activity has been identified in several kidney diseases, including IgA nephropathy,...

Advancing aHUS Understanding: The ISN’s International Forum in Prague Sets the Stage for Progress

The ISN's aHUS International Forum took place from December 8-10 in Prague, the Czech Republic. The forum brought together over 80 experts in atypical hemolytic uremic syndrome (aHUS) from around the globe. Participants at the ISN aHUS International Forum Topics covered included terminology, evaluation, treatment of native disease, Factor H antibody and treatment, transplant, and non-complement...