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Check out this month’s ISN-ACT trial list

Once a month, we collect and publish a list of important nephrology trials from the latest medical literature. Each trial is reviewed in context and their risk of bias in seven key areas assessed.

The ISN-ACT is an initiative of the ISN intended to leverage existing infrastructures within ISN, in order to improve global nephrology community participation in clinical trial research, through a series of activities and initiatives.

Here is is what we have picked for September!

Iron-based binder may lower FGF-23 levels

Ferric Citrate Decreases Fibroblast Growth Factor 23 and Improves Erythropoeitin Responsiveness in Hemodialysis Patients
Maruyama, et al. Am J Nephrol. 2018;47(6):406-414

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Mixed results for electronic medical record-based medication self-management program in hypertension

Effect of Electronic Health Record–Based Medication Support and Nurse-Led Medication Therapy Management on Hypertension and Medication Self-management: A Randomized Clinical Trial
Persell, et al. JAMA Intern Med. 2018;178(8):1069–1077

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Bicarbonate therapy may preserve renal function and muscle mass

Correction of metabolic acidosis improves muscle mass and renal function in chronic kidney disease stages 3 and 4: a randomized controlled trial
Dubey, et al. Nephrol Dial Transplant. 2018 Jul 24. doi: 10.1093/ndt/gfy214

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Lower doses of mycophenolate may be effective in lupus nephritis

Low dose mycophenolate mofetil versus cyclophosphamide in the induction therapy of lupus nephritis in Nepalese population: a randomized control trial
Sedhain et al. BMC Nephrology. 2018;19:175

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Electronic record based identification of CKD patients and associated treatment targets can boost adherence to recommended therapies

Impact of a Primary Care CKD Registry in a US Public Safety-Net Health Care Delivery System: A Pragmatic Randomized Trial
Tuot, et al. Am J Kidney Dis. 2018;72(2):168-177

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Patient self-management program reduces sodium intake in hemodialysis patients

Effectiveness of self-management support in maintenance haemodialysis patients with hypertension: A pilot cluster randomized controlled trial
Huang, et al. Nephrology. 2018;23(8):755-763

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