Check out this month’s ISN-ACT trial listiclaron
Once a month, we collect and publish a list of important nephrology trials from the latest medical literature. Each trial is reviewed in context and their risk of bias in seven key areas assessed.
The ISN-ACT is an initiative of the ISN intended to leverage existing infrastructures within ISN, in order to improve global nephrology community participation in clinical trial research, through a series of activities and initiatives.
Here is is what we have picked for September!
Iron-based binder may lower FGF-23 levels
Ferric Citrate Decreases Fibroblast Growth Factor 23 and Improves Erythropoeitin Responsiveness in Hemodialysis Patients
Maruyama, et al. Am J Nephrol. 2018;47(6):406-414
Mixed results for electronic medical record-based medication self-management program in hypertension
Effect of Electronic Health Record–Based Medication Support and Nurse-Led Medication Therapy Management on Hypertension and Medication Self-management: A Randomized Clinical Trial
Persell, et al. JAMA Intern Med. 2018;178(8):1069–1077
Bicarbonate therapy may preserve renal function and muscle mass
Correction of metabolic acidosis improves muscle mass and renal function in chronic kidney disease stages 3 and 4: a randomized controlled trial
Dubey, et al. Nephrol Dial Transplant. 2018 Jul 24. doi: 10.1093/ndt/gfy214
Lower doses of mycophenolate may be effective in lupus nephritis
Low dose mycophenolate mofetil versus cyclophosphamide in the induction therapy of lupus nephritis in Nepalese population: a randomized control trial
Sedhain et al. BMC Nephrology. 2018;19:175
Electronic record based identification of CKD patients and associated treatment targets can boost adherence to recommended therapies
Impact of a Primary Care CKD Registry in a US Public Safety-Net Health Care Delivery System: A Pragmatic Randomized Trial
Tuot, et al. Am J Kidney Dis. 2018;72(2):168-177
Patient self-management program reduces sodium intake in hemodialysis patients
Effectiveness of self-management support in maintenance haemodialysis patients with hypertension: A pilot cluster randomized controlled trial
Huang, et al. Nephrology. 2018;23(8):755-763