Pathophysiology of the glomerulus: KI tells the storyReema Parmar
To celebrate ISN’s 60th anniversary throughout 2020, Kidney International’s “Milestones in Nephrology” series launches with a review of the development in understanding of the pathophysiology of the glomerulus, highlighting several original articles published in KI:
The glomerular signature in patients with hematuria (Kenneth F. Fairley and Douglas F. Birch, 1982);
The permselectivity of the glomerular capillary wall (Ramsay L.S. Chang, William M. Deen, Channing R. Robertson, and Barry M. Brenner, 1975);
T-cells and macrophages in rapidly progressive glomerulonephritis: clinicopathologic correlations (Bolton W.K., Innes D.J. Jr., Sturgill B.C., Kaiser D.L., 1987);
Glomerular hemodynamic changes vs. hypertrophy in experimental glomerular sclerosis (Yoshida Y., Fogo A., Ichikawa I., 1989); and
Genetic studies into inherited and sporadic hemolytic uremic syndrome (Warwicker P., Goodship T.H.J., Donne R.L., et al., 1998).
These articles, despite sometimes triggering controversy, opened the way for improved patient care, innovative therapeutic intervention, and genetic screening.
These groundbreaking papers from KI, shared monthly, will be discussed by an editor from KI and put into perspective of the most recent advances in the field.